Randomized controlled trials (RCTs) are considered the “gold standard” in clinical medicine. Perhaps for this reason, health authorities all over the world have assumed the universal validity of RCTs and have not recognized that RCT results may not be valid everywhere or for the epidemiology of infectious diseases. Using the Pfizer-BioNTech vaccine trial as a case study, we illustrate the limitations of the RCT and show that the results may be inappropriate for COVID-19 epidemiology. This critique explains why health authorities have not recognized that the vaccines have failed to stem the growth of the COVID-19 pandemic. This insight has also broader implications for the global pharmaceutical industry. Continue reading
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